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KMID : 0357919870210020075
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Korean Journal of Pathology
1987 Volume.21 No. 2 p.75 ~ p.81
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A Histopathologic, Histochemical and Immunocytochemical Study of Cardiac Myxoma
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Abstract
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The immunoreactivities of surgically removed 16cardiac myxomas were studies for
factor Ⅷ-related Ag (F Ⅷ-RA), Ulex europaeus agglutinin I (UEA-I) and desmin α
1-antichymotrypsin, and this study was accompained by a clinicopathologic
review. More than 50% of the patients with cardiac myxomas were in their fourth and
fifth decades, and cardiac myxomas were much more common in women than in men.
All but on occurred in the left atrium, and the majority were attached to the atrial
septum, usually in the region corresponding to the fossa ovalis.
In one case, an atrial myxoma recurred 37 months after the initial excision.
Microscopically, the myxomas contained a myxoid matrix composed of acid
mucopolysaccharides within which were embedded polygonal cells. The cells forming
both the surface and complicated vascular like channels throughout the myxoid stroma
tested positive for F Ⅷ-RA and UEA-Ⅰ. The outer cell layers of the complex vascular
structures demonstrated variable staining for F Ⅷ-RA, while isolated bundles of smooth
muscle cells were present and stained for desmin.
A small number of the so-called myxoma cells, immunoreactive for α
1-antichymotrypsin which were not laden with hemosiderin pigment but
were similar to histiocytes, were present particularly around the areas of hemorrhage.
These findings support the current view that cellular and histologic heterogeneity arose
from the divergent differentiation of multipotential mesenchymal cells. In particular, it
remains to be confirmed by further study whether or not true histiocytic differentiation
occurs.
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KEYWORD
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